GENEX Fisetin 100mg/Serving (60 Capsules) | Antioxidant That Supports Healthy Aging and Brain Wellness - Non-GMO, Gluten Free, Vegetarian - 2 Mont...

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Fisetin helps Cognition by "killing" Zombie Cells -- It seems to have improved my cognition somewhat since taking Fisetin daily

So this is Fisetin, at a dosage of 100 mg per capsule. The capsules are normal-sized and easy to swallow, and the bottle comes with 60 capsules, so a 2-month supply if taken at the recommended dose of one capsule per day. Methylcellulose is listed as the other ingredient, and there is a GMP stamp on the bottle, which also notes that the product is distributed by a company giving a US address, but there is no information of where the product is manufactured. The bottle also states that the product is lab tested. The recommended dosage is one capsule, taken in the morning with water, with or without food. This had me a bit skeptical, for two reasons - first, fisetin is claimed to have pretty poor absorption, but be fat soluble, which usually points to it being helped by a fatty meal (or yogurt, or olive oil). Second, there are no human studies pointing to an appropriate dosage. I decided to try fisetin out after hearing about it from Dr Sinclair, recommending it as a potential senolytic. I got interested in it as something that might potentially be synergistic with fasting in that aspect. But there was no dosage recommendation... I took it for two weeks at the manufacturer-recommended dose of 100 mg/day. At that dosage, I tolerated it really well, but it would fall into the "faith supplement" category - absolutely no clue if it was doing anything or not. Then I decided to dive a bit into the literature, which was when I realized the lack of human studies - all I could find was a currently ongoing clinical trial, administering fisetin for two days in a row at what is mentioned by other reviewers, 20 mg/kg of body weight. Which would get me roughly to 1400 mg (darn extra COVID weight). So I stopped taking it for a week to clear my system, and then went for it, accompanying the fisetin with a nice cup of yogurt. When I tried that out, my reaction would probably have disqualified me from that trial - I got pretty strong fatigue, and, pretty strangely, I got a flare up of RSI (which I never had before in that form). It felt like it amplified some lingering inflammation. Things subsided a couple of days later. It could have been a coincidence. Or... there are ways to try to rationalize the sensation. But, to be honest, I am currently looking at the rest of the bottle and debating what to do with it. The saner part of my brain tells me to put a hold on it until more information comes out.

I am always a little concerned when you dont know much about the company but I like that they seem to be very attuned to questions. Im glad they third party test -always good. I was taking fisetin on and off and restarted recently. I just take one per day and I have noticed a difference in my memory. When I was doing research it was really good to read that fisetin is not toxic in body even at high doses. So many studies out there with great reports on this little humble supplement. Preventative for cancer, brain, anti Inflammatory,etc. So happy I found it and GenX has a fair price. Thank you!

I am not a doctor and dont recommend taking any supplements or suggest any doses. I am reporting on the doses I found on a Google search. Do your own research on the doses and uses for Fisetin. I bought this product to start a senolytic supplement regimen. Most studies recommended 20mg per 1kg of body weight for two consecutive days. Do the math. I weigh 180lbs which is 82kg. Therefore the recommended dose would be 20mg times 82 kg = to 1600mg for two days. That was my only complaint with the product. The capsules are 100mg so it would have been 16 capsules per day for two days.