I've been taking this product on and off for 3+ years now Positives: 1. As other reviewers have posted, it really does reduce a post meal exhaustion crash, in fact, it has almost eliminated it entirely for me. Also, I feel more mentally acute throughout the day. 2. I've also noticed that my hunger has drastically decreased from where it used to be before taking this supplement. I simply don't get hungry between meals anymore, and only a little after 5 hours. 3. I've noticed that my eyes feel less strained throughout the day, can focus better also. 4. I've noticed its easier to fall asleep and stay asleep with a better balanced immune system via anti-oxidants. Negatives 1. My intestines were un-accustomed to this type of herbs and SOD w/catalase and took a while to adjust. But once you adjust, no problems. 2. A slight feeling of bloatedness and slight intestinal discomfort that has receded after 3 weeks of use, but occasionally shows up. But it's useful since you don't get hungry as often 3. My stools have gotten a tad harder and I even had a small amount (less than half a teaspoon) of blood with one or two bowl movements when I began taking 3 pills per day. However my intestines seem to have adjusted after 3 weeks, and I no longer get these types of movements and instead I think they are far healthier now than they were before I began. Fiber supplements may help your body adjust better. Recommend easing into taking this supplement so you don't over-whelm your body that doesn't have enzymes used to breaking down these types of ingredients. I will review more when I've taken it for 3 months, then again at 6 months. it is too soon to see any effects like skin quality, or hair color / grey hair returning to color. but here's hoping. Edit: Been taking for 3+ years now. Still feel healthier. I'm 38 years old and I still get carded for looking young. I took some last week before drinking rum and gin heavily and my buzz went away within two hours, and I felt normal afterward. I average 1-2 pills a day. and take 2 days off a week from them. I just gave blood a few weeks ago, and the nurses were amazed at the test results, my blood was acting like mid-20 year old. I sort of feel like this supplement helps your body maintain balance. I've noticed I can tolerate peanut butter a LOT better than I used too. In fact, foods that used to make me feel queezy or sick, my body handles them better. As far as skin health, I have much less inflammation than before taking these. June 2016: 9 months taking these now, have not gained any new gray hairs, but haven't seen any go back in color either. In fact several people remark that I look 2-3 years younger than I am. My eye sight is also slightly improved with these, mostly it seems clearer. Also, I can be outside for an hour or more without sunscreen and have no burns. ~My 70 yr old mother has been taking them for 1.5 months and is having a blood test in January, she is labeled pre-diabetic, but otherwise healthy. Will report if that changes in review at that time. ~She got results back on her blood test and no significant changes were detected in her pre-diabetic levels, which I view as a good thing, but she says she's sleeping better. ~ a few months later, and I can tell she has more color in her skin than 6 months ago, overall healthy improvement ( June 2016 ) 2019, I stopped taking for a year, and have noticed my skin still staying younger, but a few more grey hairs, so starting back up again. Also, the price of these has returned down to a more affordable amount.